Patient killed, EMS crew critically injured in I-55 crash

Pafford EMS ambulance involved in head-on collision near Wesson, Mississippi

Published on Feb. 7, 2026

A patient being transported by a Pafford EMS ambulance was killed and the two medics on board were critically injured after the ambulance was involved in a head-on crash on Interstate 55 near Wesson, Mississippi, late Friday night. The Mississippi Highway Patrol is investigating the incident.

Why it matters

Ambulance crashes involving patient transport are rare but extremely serious incidents that can have tragic consequences. This crash raises questions about the safety protocols and procedures in place for emergency medical transport, as well as the potential risks faced by EMS crews and patients on the road.

The details

According to Pafford EMS, the ambulance was traveling northbound on I-55 with two medics on board when it was struck head-on by another vehicle. The patient being transported in the ambulance was pronounced dead at the scene. Both medics were critically injured and flown to a nearby trauma center for treatment. The condition of the other driver involved in the crash was not immediately known.

  • The crash occurred late Friday night on Interstate 55 near Wesson, Mississippi.

The players

Pafford EMS

A regional emergency medical services provider that operates in several states across the southern United States.

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What they’re saying

“We are heartbroken by this incident and ask that the public keep everyone affected in their prayers. Our top priority is the safety and recovery of our injured crew members, and we are committed to supporting them throughout their recovery.”

— Pafford EMS (darkhorsepressnow.com)

What’s next

The Mississippi Highway Patrol is leading the investigation into the crash and will provide updates as more information becomes available.

The takeaway

This tragic incident underscores the inherent risks and challenges faced by emergency medical responders who are tasked with transporting critically ill or injured patients, even in the most routine of circumstances. It serves as a somber reminder of the need for continued vigilance and safety improvements in the EMS industry.