Roswell Park Teams Bring Latest Real-World Data, New Strategies to Treat Aggressive Cancers to AACR 2026

Researchers to present groundbreaking work at major cancer research conference

Apr. 14, 2026 at 1:04am

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A highly detailed, translucent X-ray-style image showing the internal structure of a cancer cell, with glowing, ghostly lines and shapes representing the complex biological processes involved in cancer treatment.Cutting-edge cancer research at Roswell Park aims to uncover new treatment strategies for aggressive forms of the disease.San Diego Today

Researchers at Roswell Park Comprehensive Cancer Center are set to present their latest findings at the American Association for Cancer Research (AACR) annual meeting in San Diego, April 17-22, 2026. The meeting will showcase advancements in cancer research and treatment strategies, including a retrospective study on the effectiveness of a targeted therapy for colorectal cancer, novel approaches to p53-mutated cancers, and breakthroughs in triple-negative breast cancer treatment.

Why it matters

The AACR annual meeting is a critical platform for sharing the latest cancer research and driving progress in the field. Roswell Park's participation highlights their commitment to advancing cancer treatment through innovative approaches and the use of real-world data, which is becoming increasingly important in oncology.

The details

The Roswell Park team will present several key findings at the AACR meeting. A retrospective study will offer insights into the effectiveness of trastuzumab deruxtecan (T-DXd/Enhertu), a targeted therapy, compared to standard chemotherapy for HER2-positive, microsatellite-stable metastatic colorectal cancer. Researchers have also developed a triple-drug regimen that demonstrates strong tumor suppression in preclinical models of p53-mutant cancers, without significant toxicity. Additionally, preclinical research from Roswell Park reveals a novel combination therapy with the potential to overcome the challenges of metastatic triple-negative breast cancer.

  • The AACR annual meeting will take place from April 17-22, 2026 in San Diego, California.
  • Roswell Park researchers will present their findings at various sessions and poster presentations throughout the conference.

The players

Roswell Park Comprehensive Cancer Center

A leading cancer research and treatment institution located in Buffalo, New York, known for its innovative approaches and commitment to advancing cancer care.

American Association for Cancer Research (AACR)

A professional organization dedicated to advancing cancer research and discovery, hosting the annual AACR meeting that attracts over 21,000 oncology professionals.

Kenan Onel, MD, PhD

A Roswell Park faculty member who will chair a session on population sciences for hematological malignancies at the AACR meeting.

Elizabeth Repasky, PhD

A Roswell Park faculty member who will co-chair a minisymposium on the tumor microenvironment and immune escape at the AACR meeting.

Song Yao, MD, PhD

A Roswell Park faculty member who will co-chair a session on molecular and genetic epidemiology of cancer risk at the AACR meeting.

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What’s next

Researchers at Roswell Park will continue to explore new treatment strategies and leverage real-world data to improve cancer care. The findings presented at the AACR meeting will likely lead to further research and clinical trials to validate the promising approaches.

The takeaway

Roswell Park's participation in the AACR meeting highlights their commitment to driving innovation in cancer research and treatment. By leveraging real-world data, exploring novel combination therapies, and fostering multidisciplinary collaboration, the Roswell Park team is poised to make significant contributions to the fight against aggressive cancers.