Kelly Osbourne Addresses 'Ozempic Face' Rumors After Dramatic Weight Loss

The discussion around Osbourne's weight loss highlights the nuances of modern weight management approaches.

Published on Feb. 16, 2026

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Kelly Osbourne's dramatic weight loss has sparked discussions about 'Ozempic face' - the potential aesthetic side effects of rapid weight loss, often associated with medications like Ozempic. While Osbourne has denied using Ozempic, the broader conversation represents a shift in how we approach weight management, body image, and the role of pharmaceuticals. The future of weight loss is likely to involve more personalized, holistic approaches that combine lifestyle interventions, technology, and potentially, medications.

Why it matters

The spotlight on Osbourne's weight loss and 'Ozempic face' reflects a broader cultural shift in attitudes towards weight management and body image. As medications like Ozempic gain popularity, questions around accessibility, equity, and the long-term effects of rapid weight loss have become increasingly important.

The details

Medications like Ozempic (semaglutide), Wegovy, Mounjaro, and Zepbound, known as GLP-1 receptor agonists, have gained traction for their effectiveness in weight loss. These drugs, initially developed for managing type 2 diabetes, work by mimicking a natural hormone that regulates appetite and blood sugar levels. However, the rapid weight loss they can induce has led to the phenomenon of 'Ozempic face,' characterized by gauntness, sunken cheeks, new wrinkles, and loose skin on the face and neck.

  • In a February 2024 E! News interview, Kelly Osbourne addressed the 'Ozempic face' rumors and stated that Ozempic did not contribute to her 85-pound weight loss.
  • Osbourne attributed her dramatic weight loss to eliminating sugar and carbohydrates from her diet.

The players

Kelly Osbourne

An English media personality who has recently lost a significant amount of weight, sparking discussions about 'Ozempic face' and the broader landscape of weight management.

Vinni Makin, MD

An endocrinologist at the Cleveland Clinic who has provided insights into the 'Ozempic face' phenomenon.

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What they’re saying

“It's characterized by gauntness, sunken cheeks, new wrinkles and loose skin on the face and neck.”

— Vinni Makin, MD, Endocrinologist, Cleveland Clinic (Cleveland Clinic)

“My dad just died, and I'm doing the best that I can, and the only thing I have to live for right now is my family.”

— Kelly Osbourne (USA Today)

What’s next

Further research is crucial to fully understand the long-term effects of GLP-1 receptor agonists on facial structure, metabolism, and overall health. Studies are needed to determine the optimal duration of treatment, identify potential risks, and develop strategies to mitigate side effects.

The takeaway

The discussion around Kelly Osbourne's weight loss highlights the need for a more compassionate and realistic approach to discussing weight and health. As the landscape of weight management evolves, a focus on personalized, holistic solutions that prioritize long-term well-being will be essential.