MLS Predictions: Moneyline Picks for Every Matchday 6 Game

Jason Ence breaks down his top moneyline picks for every match on MLS Matchday 6, led by Inter Miami.

Apr. 4, 2026 at 1:34pm

Got story updates? Submit your updates here. ›

After a week off for an international break, the MLS campaign resumes with plenty of intriguing matchups. All 30 teams will be in action on Saturday, headlined by a Cascadia Cup match between the Vancouver Whitecaps and the Portland Timbers. However, the biggest match of the weekend could be the tilt between the San Jose Earthquakes and San Diego FC.

Why it matters

MLS Matchday 6 features several key matchups that could have significant implications on the league standings and playoff race. Fans and bettors will be closely watching these games to see how teams perform coming out of the international break.

The details

Jason Ence provides his top moneyline picks for each of the Matchday 6 games in MLS. He highlights several intriguing matchups, including the Cascadia Cup clash between the Whitecaps and Timbers, as well as the showdown between the Earthquakes and San Diego FC. Ence's picks cover the full slate of MLS action this weekend.

  • MLS Matchday 6 takes place on Saturday, April 4, 2026.

The players

Lionel Messi

A legendary Argentine soccer player who recently joined Inter Miami FC.

Timo Werner

A German soccer player who recently joined the San Jose Earthquakes.

Got photos? Submit your photos here. ›

What they’re saying

“Lionel Messi and company open the Nu Stadium for the first time, and that atmosphere is going to be tremendous. It's going to be a rough night for an Austin side that has lost both road matches this season.”

— Jason Ence, Sports Analyst

“I will be tuned in for this one. Timo Werner is already clicking for San Jose and was part of an impressive win over Vancouver. San Diego are playing quite well, and are a Top 5 club in MLS right now as far as I'm concerned. This should be a terrific showdown with no clear winner.”

— Jason Ence, Sports Analyst

What’s next

Fans and bettors will be closely watching the results of Matchday 6 to see how teams perform coming out of the international break and how the league standings start to take shape.

The takeaway

MLS Matchday 6 features several must-watch matchups that could have significant implications on the league standings and playoff race. Fans and bettors will be eager to see how teams respond after the international break and which squads can gain an early advantage in the race for the postseason.