Deadly Collision in Cairo Leaves One Dead, Three Injured

A two-vehicle crash on U.S. Route 63 claims the life of a Randolph County woman.

Published on Feb. 12, 2026

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A 75-year-old woman from Jacksonville, Missouri was killed and her 15-year-old passenger seriously injured after the woman's car pulled into the path of an SUV on U.S. Route 63 in Cairo on the evening of February 11, 2026. The driver of the SUV and her passenger also sustained injuries in the crash.

Why it matters

This tragic accident highlights the importance of safe driving practices and the need for caution when entering major highways, especially in rural areas. Fatal collisions can have a devastating impact on local communities.

The details

According to the Missouri State Highway Patrol, the 75-year-old woman attempted to enter the northbound lanes of U.S. Route 63 from Route K around 7:25 p.m. when she pulled her car into the path of the oncoming SUV, driven by a 56-year-old woman from Green Castle. The Jacksonville woman was pronounced dead at a Columbia hospital about two hours after the crash. Her 15-year-old passenger was flown to Columbia for treatment of serious injuries. The Green Castle driver sustained minor injuries, while her 59-year-old passenger had moderate injuries. Both were also taken to Columbia for medical care.

  • The collision occurred around 7:25 p.m. on Wednesday, February 11, 2026.
  • The 75-year-old woman from Jacksonville was pronounced dead at a Columbia hospital about two hours after the crash.

The players

75-year-old woman from Jacksonville

The driver of the car who pulled into the path of the oncoming SUV, resulting in her death.

15-year-old passenger

The passenger in the car driven by the 75-year-old woman, who sustained serious injuries in the crash.

56-year-old woman from Green Castle

The driver of the SUV that collided with the car, sustaining minor injuries.

59-year-old passenger

The passenger in the SUV, who sustained moderate injuries in the crash.

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The takeaway

This tragic accident serves as a sobering reminder of the importance of safe driving practices, especially when entering major highways. It highlights the need for increased awareness and caution to prevent similar incidents from occurring in the future and protect the safety of all road users.