Mayo Clinic Review Advances Personalized Care for Meningioma Patients

New research highlights innovations in diagnosis, imaging, and targeted treatments to improve outcomes and quality of life.

Apr. 18, 2026 at 2:00am

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A highly detailed, translucent X-ray photograph revealing the faint outline of a meningioma brain tumor against the dark background, conceptually illustrating the use of advanced imaging to guide personalized care.Advanced imaging techniques are enabling clinicians to better detect and monitor meningioma tumors, paving the way for more personalized, targeted treatment approaches.Rochester Today

A comprehensive new review led by Mayo Clinic is helping shape how clinicians diagnose and treat meningioma, the most common primary brain tumor, with a focus on personalized, patient-centered care and the latest advances in precision oncology.

Why it matters

Meningiomas account for about 37% of all central nervous system tumors and can significantly affect neurological function depending on their location. Traditionally, treatment decisions have relied on tumor appearance under a microscope, but this review highlights a major shift toward integrating molecular, imaging and clinical data to tailor care for each patient.

The details

Key advances include more accurate diagnosis and prognosis through new molecular classification systems, earlier detection of recurrence using advanced imaging like PET/MRI, and less invasive, safer treatments with innovations in surgical techniques and precision radiotherapy. The review also outlines new options for more complex cases, including targeted drugs, immunotherapy and radioligand therapies guided by molecular profiling and advanced imaging.

  • The review was published in Nature Reviews Clinical Oncology in April 2026.

The players

Gelareh Zadeh, M.D., Ph.D.

Chair of the Department of Neurologic Surgery at Mayo Clinic in Rochester and senior author of the review.

Mayo Clinic

A nonprofit organization committed to clinical practice, education and research, providing expert, whole-person care to everyone who needs healing.

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What they’re saying

“This work synthesizes rapidly evolving science to support more personalized care for patients with meningioma. With insights and technologies emerging quickly, there is an urgent need to translate new knowledge into clinical practice. This review helps care teams make more informed decisions to improve outcomes and quality of life for patients.”

— Gelareh Zadeh, M.D., Ph.D., Chair of the Department of Neurologic Surgery at Mayo Clinic

What’s next

The review outlines a modern, multidisciplinary approach to meningioma care that adapts to each patient's needs, whether that means active surveillance, minimally invasive surgery, highly targeted radiation therapy, or emerging options like targeted drugs, immunotherapy and radioligand therapies.

The takeaway

This comprehensive review from Mayo Clinic is helping redefine how clinicians approach the most common type of brain tumor, moving beyond a one-size-fits-all approach toward more personalized, patient-centered care that leverages the latest advances in precision oncology to improve outcomes and quality of life.