DNA on Gloves Near Guthrie Home Does Not Match Database

Forensic experts discuss lack of CODIS match in Nancy Guthrie case

Published on Feb. 22, 2026

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DNA found on gloves discovered near the home of Nancy Guthrie, a Seattle woman who went missing in 2026, does not match any profiles in the national CODIS database. Forensic experts discuss the implications of this development in the ongoing investigation.

Why it matters

The lack of a CODIS match on the DNA evidence found near Guthrie's home raises new questions about the identity of the perpetrator and the direction of the investigation. Forensic evidence is crucial in solving missing persons cases, and the inability to link the glove DNA to a known offender complicates efforts to determine what happened to Guthrie.

The details

The gloves were found approximately a mile and a half from Guthrie's home in Seattle. DNA testing was conducted, but the results did not match any profiles in the national CODIS (Combined DNA Index System) database. Forensic experts on the "Crime Stories with Nancy Grace" program discussed the significance of this development, noting that it means the DNA does not belong to a known offender in the system.

  • The gloves were found near Guthrie's home in February 2026.

The players

Nancy Guthrie

A Seattle woman who went missing in 2026.

Tami Ballard

A DNA and Crime Scene Consultant, Crime Scene Investigation and Reconstruction, and Former DNA Criminalist in the San Diego Police Dept. Crime Laboratory.

Scott Eicher

A Digital Forensics Expert, Founding Member of the FBI's Cellular Analysis Survey Team (C.A.S.T), and Former FBI Agent of 22 years; Former Homicide Detective, Currently with Precision Cellular Analysis.

Dave Mack

A Crime Stories Investigative Reporter.

Skye Lazaro

A Criminal Defense Attorney at Ray, Quinney & Nebeker.

Andrew Black

A Former Special Agent in Charge of the Tucson Office of the FBI (27 years with the FBI), Former Chicago Felony Prosecutor, and Currently the Chief of the University of Hawaii Department of Public Safety.

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The takeaway

The lack of a CODIS match on the DNA evidence found near Guthrie's home is a significant development in the investigation, as it means the perpetrator's identity is still unknown. Forensic experts will likely continue to analyze the evidence and explore other avenues to try to determine what happened to Guthrie and identify the person responsible.