Eric Dane, 'Grey's Anatomy' and 'Euphoria' Star, Dies at 53 After ALS Diagnosis

The acclaimed actor passed away following a battle with the neurodegenerative disease.

Published on Feb. 27, 2026

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Eric Dane, the acclaimed actor known for his roles in hit shows like 'Grey's Anatomy' and 'Euphoria', has died at the age of 53 after being diagnosed with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.

Why it matters

Dane's death is a tragic loss for the entertainment industry, as he was widely regarded as a talented and versatile actor who brought depth and nuance to his performances. His openness about his ALS diagnosis also sheds light on the devastating impact of this incurable disease.

The details

Dane, who rose to fame playing Dr. Mark Sloan on 'Grey's Anatomy', revealed his ALS diagnosis in 2025. The progressive disease, which affects nerve cells in the brain and spinal cord, ultimately led to his death.

  • Dane revealed his ALS diagnosis in 2025.
  • Dane passed away on February 20, 2026.

The players

Eric Dane

A renowned American actor known for his roles in popular television shows such as 'Grey's Anatomy' and 'Euphoria'.

Amyotrophic Lateral Sclerosis (ALS)

A fatal neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to loss of muscle control and function.

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What they’re saying

“Eric Dane was a true talent and his passing is a tremendous loss for the entertainment industry. His performances were always captivating and he will be deeply missed.”

— Shonda Rhimes, Producer and Showrunner (Entertainment Weekly)

“Dane's openness about his ALS diagnosis was incredibly brave and will help raise awareness about this devastating disease. He was an inspiration to all who knew him.”

— Zendaya (People Magazine)

What’s next

Dane's family and close friends are expected to hold a private memorial service to celebrate his life and legacy.

The takeaway

Eric Dane's untimely passing at the age of 53 is a tragic reminder of the immense toll that ALS takes on individuals and their loved ones. His remarkable acting career and courageous approach to his illness will continue to inspire others facing similar challenges.