Actor Eric Dane of 'Grey's Anatomy' and 'Euphoria' dies at 53 after ALS diagnosis

Dane was known for his roles in popular TV shows before his untimely passing.

Published on Feb. 27, 2026

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Eric Dane, the acclaimed actor known for his roles in hit TV shows like "Grey's Anatomy" and "Euphoria", has passed away at the age of 53 after being diagnosed with amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease.

Why it matters

Dane's death at a relatively young age due to ALS highlights the devastating impact of this terminal illness, which affects the nerve cells responsible for controlling voluntary muscle movement. His passing is a major loss for the entertainment industry and his many fans.

The details

Dane rose to fame playing Dr. Mark Sloan on the long-running medical drama "Grey's Anatomy" from 2006 to 2012. He later starred as Cal Jacobs in the HBO series "Euphoria", earning critical acclaim for his portrayal of a troubled father. Dane's ALS diagnosis was made public in late 2025, and he passed away peacefully at his home in Los Angeles.

  • Dane was diagnosed with ALS in late 2025.
  • Dane passed away on February 19, 2026 at the age of 53.

The players

Eric Dane

A popular American actor known for his roles in hit TV shows like "Grey's Anatomy" and "Euphoria". He passed away at the age of 53 after being diagnosed with ALS.

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What they’re saying

“Eric was a beloved actor and a wonderful human being. He will be deeply missed.”

— Shonda Rhimes, Creator of "Grey's Anatomy" (Variety)

“Working with Eric on 'Euphoria' was an honor. He brought so much depth and humanity to his character. This is a huge loss.”

— Sam Levinson, Creator of "Euphoria" (The Hollywood Reporter)

The takeaway

Dane's passing at a relatively young age due to the devastating effects of ALS serves as a somber reminder of the urgent need for continued research and support for those battling this terminal illness. His memorable performances and impact on the entertainment industry will not be forgotten.