Deadly Crash on US 21 in Blythewood Leaves One Dead

South Carolina Highway Patrol releases details on the multi-vehicle collision that occurred on Friday

Published on Feb. 21, 2026

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A deadly crash on US 21 in Blythewood, South Carolina on Friday left one person dead after a 2019 Hino 338 truck crossed the center line, sideswiped a Ford F150, and struck a Kia Sportage head-on, also colliding with a Lexus SUV. The Lexus then struck a Chevrolet Suburban, and the Hino truck went off the road, hit several mailboxes, and overturned.

Why it matters

Fatal multi-vehicle crashes on major highways are always concerning for public safety, and this incident on US 21 in Blythewood highlights the need for continued vigilance and safety improvements on South Carolina's roads.

The details

According to the South Carolina Highway Patrol, a 2007 Ford F150, a 2025 Kia Sportage, and a 2018 Lexus SUV were travelling southbound on US 21 when a 2008 Chevrolet Suburban and a 2019 Hino 338 truck travelling northbound were involved in the collision. The Hino 338 truck crossed the center line, sideswiped the Ford F150, and struck the Kia Sportage head-on, also colliding with the Lexus SUV. The Lexus then struck the Chevrolet Suburban. The Hino truck went off the road, hit several mailboxes, and overturned.

  • The crash occurred on Friday, February 20, 2026.

The players

2007 Ford F150

One of the vehicles involved in the southbound collision.

2025 Kia Sportage

One of the vehicles involved in the southbound collision, the driver of which suffered fatal injuries.

2018 Lexus SUV

One of the vehicles involved in the southbound collision, which then struck the northbound Chevrolet Suburban.

2008 Chevrolet Suburban

One of the northbound vehicles involved in the collision, which was struck by the Lexus SUV.

2019 Hino 338 truck

The northbound truck that crossed the center line, sideswiped the Ford F150, and struck the Kia Sportage head-on, also colliding with the Lexus SUV.

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The takeaway

This tragic crash on US 21 in Blythewood serves as a sobering reminder of the importance of safe driving practices and the need for continued infrastructure improvements and safety measures on South Carolina's highways to prevent such devastating incidents in the future.