The Pitt's Isa Briones Teases Major Tension Between Santos and Langdon in Season 2

The actress says the conflict between her character and Patrick Ball's Dr. Langdon is "leading to something" big.

Published on Feb. 28, 2026

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Isa Briones, who plays Dr. Trinity Santos in the HBO medical drama The Pitt, reveals in an exclusive interview that the tension between her character and Patrick Ball's Dr. Frank Langdon is building to a major moment in season 2. Langdon, a senior resident, was kicked out of the Pittsburgh Trauma Medical Center after Santos reported him for stealing drugs from a patient. Now, Langdon has returned to the ER after a stint in rehab, and the two are struggling to reconcile their past conflict.

Why it matters

The tension between Santos and Langdon highlights the complex dynamics within the medical staff at the hospital, as well as the challenges faced by those who report misconduct, even when it's the right thing to do. Briones' comments suggest the storyline will lead to a significant development that will impact the characters and the overall narrative of the show.

The details

In a recent episode, Santos and Langdon are forced to work together to treat a patient during a hospital IT crisis. The two fall back into their old patterns, with Santos interrupting and speaking over Langdon as they discuss the treatment plan. Briones explains that Santos is having trouble accepting Langdon's return, as she has been seen as an outsider for reporting his actions. The actress says the characters are similar in their personalities, but Langdon is more widely accepted, while Santos is perceived as "too much."

  • Season 2 sees Langdon's anticipated return to the ER after Santos turned him in for stealing drugs from a patient.
  • The tension between Santos and Langdon grows in the Feb. 26 episode of The Pitt.

The players

Isa Briones

The actress who plays Dr. Trinity Santos in the HBO medical drama The Pitt.

Patrick Ball

The actor who plays Dr. Frank Langdon, a senior resident at the Pittsburgh Trauma Medical Center.

Dr. Trinity Santos

An intern at the Pittsburgh Trauma Medical Center who reported Dr. Langdon for stealing drugs from a patient, leading to his dismissal from the hospital.

Dr. Frank Langdon

A senior resident at the Pittsburgh Trauma Medical Center who was kicked out of the hospital after Santos reported him for stealing drugs from a patient. He has since returned to the ER after a stint in rehab.

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What they’re saying

“Langdon coming back to the ER is a little unexpected for her. I don't think she necessarily knew that he was coming back. She's had a rough go of it for the past 10 months, trying to find her place in the ER.”

— Isa Briones, Actress who plays Dr. Trinity Santos (PEOPLE)

“She and Langdon are very similar people, but she is seen as, 'Oh, she's too much.' He's the same way and they're like, 'Oh my God, he is the best.' I think that is a bigger comment on the society we live in. But now with him coming back, she has to face someone who really made her feel like she did not belong there.”

— Isa Briones, Actress who plays Dr. Trinity Santos (PEOPLE)

What’s next

The tension between Santos and Langdon is expected to 'combust' as they are forced to continue working together in the ER, according to Briones.

The takeaway

The conflict between Santos and Langdon highlights the complex social dynamics within the medical profession, where personal biases and perceptions can impact how individuals are treated, even when they are doing the right thing. The storyline suggests the show will explore these themes in depth as the season progresses.