Exploring the Impact of Alcohol on the Brain and Body

From the highs of intoxication to the lows of addiction, a look at our complex relationship with alcohol

Jan. 30, 2026 at 10:15am

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This episode of the WHYY podcast explores our complex relationship with alcohol - why we consume it, how it affects us, and when it's time to quit. The show features interviews with a recovering alcoholic surgeon, a look at the 'California sober' trend, and a visit to a zero-proof cocktail bar catering to sober socializing.

Why it matters

Alcohol use and abuse is a major public health issue, with significant impacts on individual health, relationships, and society as a whole. Understanding the neuroscience behind alcohol's effects, as well as emerging trends in sobriety, can help people make more informed choices about their own alcohol consumption.

The details

The episode delves into how alcohol affects the brain and body, featuring an interview with surgeon and recovering alcoholic Charles Knowles. It also explores the 'California sober' trend, where some former drinkers embrace cannabis and psychedelics as an alternative to alcohol. Additionally, the show visits a zero-proof cocktail bar in Philadelphia that caters to sober socializing.

  • The episode was published on January 30, 2026.
  • It comes at the end of 'Dry January', a popular movement to abstain from drinking for the month.

The players

Charles Knowles

A surgeon and physician who was a recovering alcoholic and has written a book on the impact of alcohol on the body and culture.

Bar Palmina

A zero-proof cocktail bar in Philadelphia that provides a sober social environment for people looking to avoid alcohol.

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What they’re saying

“Alcohol stopped being fun — and started affecting his health and his life.”

— Charles Knowles, Surgeon and recovering alcoholic (whyy.org)

What’s next

The episode does not mention any clear next steps or future newsworthy events.

The takeaway

This episode highlights the complex and often problematic relationship many people have with alcohol, while also showcasing emerging trends and alternatives that are helping people navigate sobriety and maintain social connections without relying on drinking.