Emerging Research Links Popular Sweetener Erythritol to Stroke and Heart Risks

Erythritol, a widely used sugar substitute, may compromise the blood-brain barrier and disrupt blood vessel regulation, potentially increasing cardiovascular risks.

Published on Feb. 18, 2026

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Erythritol, a popular low-calorie sweetener, is facing increased scrutiny as new research suggests it may not be as harmless as previously believed. Studies indicate erythritol consumption could be linked to an elevated risk of cardiovascular events, including heart attack and stroke, as well as potential damage to the brain's protective blood-brain barrier.

Why it matters

Erythritol is a common additive in a variety of food and beverage products, often marketed as a healthier alternative to sugar. However, these emerging findings raise concerns about the long-term safety of consuming erythritol, especially for individuals with pre-existing cardiovascular conditions or risk factors.

The details

Researchers have discovered that erythritol may compromise the integrity of cells within the blood-brain barrier, a crucial protective mechanism for the brain. This damage could make the brain more susceptible to blood clot formation, a leading cause of stroke. Additionally, erythritol was found to disrupt the delicate balance of blood vessel regulation, potentially leading to dangerously constricted blood vessels and reduced blood flow to the brain.

  • In March 2023, a study published by the National Institutes of Health (NIH) found that higher blood levels of erythritol were associated with an increased risk of heart attack and stroke.
  • In February 2023, a study published in Nature Medicine demonstrated that erythritol can enhance platelet reactivity and promote thrombosis, the formation of blood clots.

The players

University of Colorado

Researchers at the University of Colorado conducted a laboratory study exposing blood-brain barrier cells to erythritol concentrations comparable to those achieved after consuming a soft drink sweetened with the compound.

Dr. Stanley Hazen

A researcher at the Cleveland Clinic who led the NIH study that found a correlation between elevated erythritol levels and adverse cardiovascular events.

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What’s next

Further research is needed to fully understand the long-term effects of erythritol consumption and its potential impact on cardiovascular health.

The takeaway

Consumers should be aware of the potential risks associated with high intake of erythritol, and individuals with pre-existing cardiovascular conditions or risk factors may want to discuss their erythritol consumption with their healthcare provider.