New Study Links PFAS Exposure to Weakened Bones in Teens

Research highlights potential long-term health impacts of 'forever chemicals'

Mar. 22, 2026 at 5:05pm

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A new study published in the Journal of the Endocrine Society has found a correlation between exposure to per- and polyfluoroalkyl substances (PFAS), often called 'forever chemicals', and lower bone density in adolescents. The research adds to growing evidence that early-life PFAS exposure may have lasting health consequences, particularly during critical developmental windows.

Why it matters

PFAS are ubiquitous in the environment and can bioaccumulate in the human body, raising concerns about their long-term health impacts. Adolescence is a key period for building strong bones, and this study suggests that reducing PFAS exposure during this time could be crucial for maintaining bone health throughout life and reducing risks of fractures and osteoporosis.

The details

Researchers analyzed data from 218 adolescents participating in a long-term study, finding that higher levels of perfluorooctanoic acid (PFOA) in the blood were associated with lower forearm bone density at age 12. The relationship between other PFAS compounds and bone density varied depending on the timing of exposure, indicating certain developmental stages may be more vulnerable. The study also found the association was stronger in females than in males.

  • Blood samples were collected at delivery and at ages 3, 8, and 12.
  • Bone density was measured at age 12.

The players

Jessie P. Buckley, Ph.D., M.P.H.

Researcher at the UNC Gillings School of Global Public Health.

HOME Study

A long-term study tracking pregnancy and birth outcomes in Cincinnati that contributed to this research.

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What they’re saying

“Adolescence is a key period for building strong bones, and achieving optimal bone mass during this time can reduce lifelong risks of fractures and osteoporosis.”

— Jessie P. Buckley, Researcher

What’s next

Further research is needed to fully understand the long-term effects of PFAS exposure on bone development and overall health. Scientists are particularly interested in identifying specific windows of vulnerability and developing strategies to mitigate the risks.

The takeaway

This study highlights the potential long-term health consequences of exposure to PFAS, often called 'forever chemicals', during critical developmental periods. Reducing PFAS contamination in the environment and consumer products remains an important public health priority.