Exercise During Chemotherapy Boosts Physical and Mental Health

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A recent study published in JNCCN-Journal of the National Comprehensive Cancer Network has found that a tailored exercise program can significantly improve physical function and cognitive health for individuals receiving chemotherapy. The study, led by experts like Dr. Karen Mustian at the Wilmot Cancer Institute, demonstrates that structured exercise, including walking and resistance band exercises, can help cancer patients better maintain their activity levels and mental sharpness compared to those who don't exercise.

Why it matters

The concept of 'exercise oncology' - the integration of exercise into cancer care - is gaining momentum as researchers discover the profound benefits. Up to 75% of cancer patients experience 'chemo brain,' which can impact memory, concentration, and daily tasks. This study shows that a personalized exercise program offers a promising, non-pharmacological approach to mitigate these effects and improve quality of life.

The details

Dr. Mustian developed the EXCAP (Exercise Prescription for Cancer Patients) program in collaboration with the American College of Sports Medicine. The low-cost, home-based program focuses on progressive aerobic walking and resistance band exercises, making it accessible to a wide range of patients. Interestingly, the study found the benefits were most pronounced in patients receiving chemotherapy every two weeks, potentially due to differences in drug toxicities and side effects.

• The study was published on March 14, 2026.

What they’re saying

What’s next

The University of Rochester/National Cancer Institute Community Oncology Research Program (NCORP) Research Base is facilitating nationwide clinical trials to further explore the integration of exercise into standard cancer care.