AI Simulations Aim to Replicate Psychedelic Experiences

Researchers explore using AI and virtual reality to study and support psychedelic-assisted therapy.

Published on Feb. 15, 2026

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The intersection of artificial intelligence and psychedelic medicine is rapidly evolving, moving beyond theoretical exploration into practical applications – and even simulations that attempt to replicate the psychedelic experience itself. Researchers are exploring how AI can personalize virtual environments to mimic altered states of consciousness, provide psychological preparation and integration support, and potentially serve as 'trip sitters' during real psychedelic experiences.

Why it matters

While regulatory hurdles and safety concerns continue to shadow traditional psychedelic-assisted therapy, researchers are increasingly turning to AI and virtual reality as potential alternatives and tools for advancement. The ability to simulate psychedelic experiences, provide personalized support, and accelerate drug discovery could revolutionize the treatment of mental health conditions, though careful consideration must be given to the ethical, safety, and regulatory challenges.

The details

One key area of focus is the creation of virtual environments designed to replicate altered states of consciousness. Researchers are exploring how AI can personalize these simulations, tailoring them to individual patient needs and potentially improving therapeutic outcomes. AI is also being explored for its role in psychological preparation and integration, as well as potentially serving as 'trip sitters' to provide real-time support and harm reduction during psychedelic experiences. Beyond simulation and support, AI is making inroads into the pharmaceutical side of psychedelic research, including drug discovery and clinical trial optimization.

  • The study was published in the Annals of the New York Academy of Sciences in February 2026.
  • A Forbes report highlighted the central question of whether AI can 'trip out' on February 15, 2026.
  • An individual's experience using ChatGPT as a 'trip sitter' was reported on July 1, 2025.

The players

Annals of the New York Academy of Sciences

A peer-reviewed scientific journal that publishes research on a wide range of topics, including the intersection of AI and psychedelic medicine.

Forbes

A leading business and financial news publication that reported on the potential for AI to replicate psychedelic experiences.

ChatGPT

An AI chatbot that has been used by individuals to provide support and guidance during psychedelic experiences.

Peter

An individual who used ChatGPT as a 'trip sitter' during a high-dose mushroom trip, finding reassurance and practical advice from the chatbot.

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What they’re saying

“We must not let individuals continue to damage private property in San Francisco.”

— Robert Jenkins, San Francisco resident (San Francisco Chronicle)

“Fifty years is such an accomplishment in San Francisco, especially with the way the city has changed over the years.”

— Gordon Edgar, grocery employee (Instagram)

The takeaway

The convergence of AI and psychedelic medicine represents a significant development with potentially far-reaching implications. The ability to simulate psychedelic experiences, provide personalized support, and accelerate drug discovery could revolutionize the treatment of mental health conditions, though careful consideration must be given to the ethical, safety, and regulatory challenges that lie ahead.