Can NAD Plus Supplements Reverse the Aging Process? Doctors Weigh In

NAD+ supplements have gained popularity for their purported anti-aging benefits, but do the pros outweigh the potential cons?

Published on Feb. 12, 2026

Got story updates? Submit your updates here. ›

Experts discuss what NAD+ is, how it differs from NADH, the potential benefits and side effects of NAD+ supplements, and whether they can actually reverse the aging process. Doctors caution that more research is needed, and that NAD+ supplements should be approached with care and under medical supervision.

Why it matters

As people age, their natural NAD+ levels decline, which can lead to fatigue and skin aging. NAD+ supplements have been touted as a way to combat these effects, but it's important for consumers to understand the science behind these claims and any potential risks.

The details

NAD+ is a coenzyme found in all living cells that helps create energy and repair DNA. It also regulates the circadian rhythm and is involved in the function of sirtuins, proteins that help regulate cell survival and aging processes. While NAD+ supplements are generally considered safe, they can cause side effects like abdominal pain, nausea, dizziness, and sleep disruption. Experts caution that NAD+ supplements should not be viewed as a "magic fix" to reverse aging, but they may help slow down certain signs of aging by boosting the body's repair systems. However, more clinical trials are needed to fully establish their efficacy in aging prevention.

  • A 2023 study examined the effects of nicotinamide riboside and nicotinamide mononucleotide oral supplementation.

The players

Dr. Konstantin Vasyukevich

A New York-based facial plastic surgeon who often discusses aging with patients.

Nayan Patel

A doctor of pharmacy and founder of Auro Wellness.

Dr. Jonathan Jennings

A board-certified internist with Medical Offices of Manhattan and contributor to Lab Finder.

Got photos? Submit your photos here. ›

What they’re saying

“[NAD+] can do a few cool things. It can help with skin health by promoting DNA repair and fighting oxidative stress, which is a big reason skin ages. It can also give you more energy by helping your cells make more [adenosine triphosphate or ATP] -- that's the energy your body runs on.”

— Dr. Konstantin Vasyukevich, Facial Plastic Surgeon

“It is important to consult your health professional prior to supplementation because safety has not been confirmed for certain populations such as pregnant [people] and children.”

— Dr. Jonathan Jennings, Internist

“NAD+ supplements can help by boosting the body's repair systems, which may reduce wrinkles and other signs of aging over time. They won't completely stop aging, but they could help your cells stay healthier and function better, which might slow things down a little.”

— Dr. Konstantin Vasyukevich, Facial Plastic Surgeon

What’s next

More clinical trials are needed to fully establish the efficacy of NAD+ supplements in reversing or slowing the aging process.

The takeaway

While NAD+ supplements show promise in potentially slowing certain signs of aging, they should not be viewed as a magic solution. Experts recommend approaching them with caution, under medical supervision, and in conjunction with a healthy lifestyle that includes regular exercise, a balanced diet, and stress management.