Study Suggests Eating Less Protein May Slow Liver Cancer Growth

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A new study published in Science Advances has found that when the liver fails to properly eliminate ammonia, a byproduct of protein metabolism, it can increase the risk of liver cancer tumor growth. The researchers discovered that tumors are able to use ammonia to produce essential molecules for cell division and survival, allowing them to thrive in unfavorable conditions. By putting mice on a low-protein diet to reduce ammonia production, the study showed tumor growth was slowed and survival rates increased.

Why it matters

This research provides new insights into the link between diet, liver function, and cancer progression. It suggests that for those with liver disease or damage that impairs proper ammonia regulation, reducing protein intake could be an effective way to help slow the growth of liver tumors.

The details

The study, led by Wei-Xing Zong at Rutgers University, found that impaired diversion of ammonia into biological pathways promotes cancer cell growth, including the production of molecules essential for tumor survival and rapid cell division. Researchers tested this by putting mice on a low-protein diet, which reduced ammonia levels and resulted in slower tumor growth and increased survival rates across multiple cancer models.

• The study was published in the journal Science Advances on March 23, 2026.

What they’re saying

What’s next

Researchers aim to better understand how dietary interventions targeting ammonia levels can be safely applied in clinical settings to help manage liver cancer progression.