Scientists Discover Robust DNA-Binding Proteins from Extreme Environments

New proteins could enhance rapid medical tests for infectious diseases

Published on Feb. 11, 2026

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An international research team led by Durham University has uncovered previously unknown DNA-binding proteins from extreme environments like Icelandic volcanic lakes and deep-sea vents. These proteins are highly stable under harsh conditions and have been shown to improve the speed and sensitivity of loop-mediated isothermal amplification (LAMP) tests used to detect viruses, bacteria, and parasites. The findings highlight the value of bioprospecting in extreme habitats for new biological tools with applications in biotechnology and medicine.

Why it matters

The discovery of these robust DNA-binding proteins from extreme environments could lead to significant advancements in rapid diagnostic testing for infectious diseases. LAMP tests that incorporate these proteins could provide faster, more sensitive, and more reliable detection of pathogens without the need for complex lab equipment, which is especially valuable in resource-limited settings.

The details

The research team analyzed genetic material from Icelandic volcanic lakes and deep-sea vents in the North Atlantic Ocean to identify previously unknown DNA-binding proteins. Using next-generation DNA sequencing, they were able to search large databases of potential proteins and select those that were able to bind to single-stranded DNA and remain stable under extreme conditions. Further laboratory testing showed that the newly discovered proteins have exceptional thermal stability, making them well-suited for use in biotechnology and medicine. One of the proteins was demonstrated to improve the performance of LAMP diagnostic tests, enhancing the speed and sensitivity of detecting genetic material from viruses like SARS-CoV-2, as well as DNA from other infectious agents.

  • The international research team conducted the study in 2026.
  • The findings were published on February 11, 2026.

The players

Durham University

The lead institution of the research team that discovered the new DNA-binding proteins.

Professor Ehmke Pohl

The lead investigator of the study from Durham University.

ArcticZymes

A Norwegian biotechnology company that is collaborating with the researchers to explore commercial applications of the new proteins.

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What they’re saying

“This work highlights the enormous potential of bioprospecting from extreme habitats. The results are not only important for the bioeconomy, but they also provide the basis for all Artificial Intelligence (AI) methods in protein structure prediction and protein design.”

— Professor Ehmke Pohl, Lead investigator of the study (Mirage News)

What’s next

The research team is continuing to search for additional DNA-binding proteins from extreme environments, with new candidates already identified and under investigation. Improved versions of the proteins are being designed, and new LAMP tests are being developed for neglected tropical diseases like leishmaniasis and Chagas disease, in collaboration with researchers at Durham University's Biosciences Department.

The takeaway

The discovery of these robust DNA-binding proteins from extreme environments demonstrates the value of bioprospecting in remote and challenging habitats. These proteins have the potential to significantly enhance rapid diagnostic testing for infectious diseases, providing faster, more sensitive, and more reliable detection of pathogens without the need for complex laboratory equipment.