Missouri Lawmakers Debate Psychedelic Clinical Trials

Proposed legislation could allow use of psilocybin and ibogaine for certain veterans and first responders.

Mar. 31, 2026 at 2:49am

A vibrant, neon outline of a human brain against a dark background, symbolizing the potential of psychedelic therapies to address mental health challenges.Proposed legislation in Missouri could allow clinical trials of psychedelic treatments for certain veterans and first responders.Jefferson City Today

The Missouri House is set to approve legislation that could establish in-state clinical trials for the use of psilocybin and ibogaine, two psychedelic substances, to treat certain mental health conditions in eligible veterans and first responders. The bill outlines specific criteria for who would qualify for the treatments, as well as guidelines for administration.

Why it matters

This legislation represents a growing interest in exploring the potential therapeutic benefits of psychedelics, particularly for populations like veterans and first responders who face high rates of mental health challenges. If passed, it could pave the way for further research and access to these treatments in Missouri.

The details

House Bill 1717 would allow the use of psilocybin and ibogaine, which are currently classified as Schedule I drugs by the federal government, in clinical trials for eligible patients. To qualify, individuals must be 21 or older, suffer from PTSD, major depression, substance use disorder, or require end-of-life care, and enroll in a study approved by the Department of Mental Health. The bill also outlines requirements for facilitators who would administer the substances and guidelines for testing the psilocybin.

  • The Missouri House is set to approve the legislation in the coming weeks.

The players

Missouri House

The lower chamber of the Missouri state legislature that is expected to approve the psychedelic clinical trials legislation.

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What’s next

If the bill passes the House, it will move to the Missouri Senate for consideration.

The takeaway

This proposed legislation reflects a growing interest in exploring the potential therapeutic benefits of psychedelics, particularly for populations facing high rates of mental health challenges. If passed, it could pave the way for further research and access to these treatments in Missouri.