University Hospitals Partners with OneDose for Medication Safety

First major health system to deploy eMACC, a digital EMS tool reducing med errors by over 40%

Published on Feb. 22, 2026

Got story updates? Submit your updates here. ›

University Hospitals has partnered with OneDose to deploy eMACC, a first-of-its-kind digital medication administration tool for emergency medical services (EMS). The eMACC system modernizes the proven Medication Administration Cross-Check (MACC) protocol, eliminating human bias during medication verification, reducing wrong-vial and wrong-dose errors, and creating a clear digital verification trail. This system-wide deployment across over 300 EMS agencies in Ohio represents a major advancement in out-of-hospital patient safety.

Why it matters

Medication errors are a persistent challenge in emergency medical care, putting patient lives at risk. By adopting the eMACC system, University Hospitals is taking a proactive step to enhance medication safety standards and improve clinical decision-making for EMS providers in the field. This partnership sets a new benchmark for medication safety in the prehospital setting.

The details

The eMACC system was developed in partnership between OneDose and Dr. Paul Misasi, the creator of the original MACC protocol. The digital tool brings the proven MACC workflow directly into the hands of EMS clinicians, eliminating human bias and creating a clear digital verification trail. University Hospitals' EMS Institute became involved in the beta testing of eMACC early in its development, and the health system has now rolled out the system as the centralized platform for its EMS protocols, medication dosing, and resuscitation support tools.

  • In January 2025, University Hospitals rolled out the OneDose app as the centralized location for its EMS protocols.
  • In the fall of 2025, University Hospitals became part of the eMACC beta testing program.

The players

University Hospitals

A major health system in Ohio that has partnered with OneDose to deploy the eMACC medication safety system across its network of over 300 EMS agencies.

OneDose

A healthcare technology company that developed the eMACC digital medication administration tool in partnership with Dr. Paul Misasi, the creator of the original MACC protocol.

Dr. John Hill

The EMS Medical Director at University Hospitals of Cleveland who was instrumental in introducing the OneDose system and eMACC tool to the health system.

Dr. Donald Spaner

The Chief Medical Officer and EMS Medical Director at University Hospitals who oversees the health system's responsibility to ensure EMS providers have the safest and most reliable tools available.

Dr. Paul Misasi

The creator of the original Medication Administration Cross-Check (MACC) protocol, who partnered with OneDose to develop the digital eMACC system.

Got photos? Submit your photos here. ›

What they’re saying

“University Hospitals continues to lead the way in prehospital innovation. Collaborating directly with UH leadership has helped shape OneDose into a platform capable of supporting large-scale systems. The system-wide deployment of eMACC sets a new benchmark for medication safety across more than 300 EMS agencies.”

— Tristen Hazlett, Founder and Chief Executive Officer of OneDose

“At University Hospitals EMS Institute, our responsibility is to ensure that the clinicians serving our communities have the safest, most reliable tools available. The first system-wide deployment of OneDose across Ohio represents a major advancement in out-of-hospital patient safety.”

— Dr. Donald Spaner, Chief Medical Officer and EMS Medical Director at University Hospitals

What’s next

University Hospitals plans to continue working closely with OneDose to further refine and expand the eMACC system, with the goal of setting a new standard for medication safety in the prehospital setting across the state of Ohio and beyond.

The takeaway

By partnering with OneDose to deploy the innovative eMACC medication verification system, University Hospitals is demonstrating a commitment to patient safety and clinical excellence in emergency medical care. This collaboration represents a significant step forward in modernizing medication administration protocols and reducing the risk of errors that can have devastating consequences for patients.