Doctors Emphasize Holistic Approach for GLP-1 Medications

Combining weight loss drugs with exercise, mental health support, and lifestyle changes is key for long-term success.

Mar. 29, 2026 at 9:05pm

The rise of GLP-1 receptor agonists like Ozempic has been nothing short of phenomenal, with nearly one in five Americans trying these medications. However, doctors are emphasizing that these drugs are most effective when combined with a holistic approach to health, including regular exercise, smart food choices, and mental health support. The story of Jelon Smart, who lost 110 pounds by incorporating a rigorous exercise regimen, underscores this point. Experts like Dafina Allen and Gerald Onuoha stress the importance of fundamental health practices and addressing emotional responses related to food and body image.

Why it matters

As more people experience the benefits and potential plateaus of GLP-1 medications, a crucial message is emerging: these drugs are most effective when combined with a comprehensive approach to health and wellness. This story highlights the need for a balanced strategy that addresses both physical and mental well-being, ensuring sustainable weight management and overall improved health outcomes.

The details

The story follows the journey of Jelon Smart, a caterer from Savannah, Georgia, who turned to Ozempic on her doctor's recommendation to address debilitating ankle pain from Achilles tendinitis. While the initial weight loss of 30 pounds was encouraging, Smart's progress stalled until she incorporated a rigorous exercise regimen, hitting the gym six days a week. This holistic approach ultimately led to Smart losing a total of 110 pounds and alleviating her ankle pain. Experts like Dafina Allen, an obesity medicine physician in Saginaw, Michigan, and Gerald Onuoha, an internal medicine physician in Nashville, Tennessee, emphasize the enduring importance of fundamental health practices, such as regular exercise, smart food choices, and plenty of sleep, in aiding weight loss and maintaining it. They also stress the connection between physical and mental health, noting that GLP-1s can trigger emotional responses related to food and body image, underscoring the need for mental health support.

  • Jelon Smart initially lost 30 pounds on Ozempic without lifestyle changes.
  • After incorporating a rigorous exercise regimen, Smart ultimately lost a total of 110 pounds.

The players

Jelon Smart

A caterer from Savannah, Georgia, who lost 110 pounds by combining Ozempic with a rigorous exercise regimen.

Dafina Allen

An obesity medicine physician in Saginaw, Michigan, who emphasizes the importance of fundamental health practices like exercise and smart food choices for sustained weight loss and well-being.

Gerald Onuoha

An internal medicine physician in Nashville, Tennessee, who stresses the importance of seeking mental health support when using GLP-1 medications.

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What they’re saying

“I went from 285 to 175" pounds.”

— Jelon Smart

“Regular exercise, smart food choices, plenty of sleep – those basic, healthy lifestyle choices are not only going to aid you lose weight on a weight loss drug but also help you keep it off.”

— Dafina Allen, Obesity Medicine Physician

“Making sure that you're talking to people about your problems, whether it's a family member or a licensed professional, I think goes a long way.”

— Gerald Onuoha, Internal Medicine Physician

What’s next

Experts predict that the GLP-1 landscape will continue to evolve, with a focus on more personalized treatment plans, combination therapies, increased behavioral support, improved accessibility, and novel delivery methods.

The takeaway

This story highlights the importance of a holistic approach to weight management, where GLP-1 medications are combined with regular exercise, smart food choices, and mental health support to achieve sustainable results and overall improved health outcomes.