Strategies to Reduce Depression Relapse Risk

Experts share tips to lower the probability of recurring depressive episodes

Apr. 7, 2026 at 5:08am

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A minimalist design in the style of Keith Haring where the outline of a human brain is defined entirely by vibrant, glowing neon lines against a deep, dark background, emphasizing the complex shape and electrical activity of the organ involved in depression.Visualizing the intricate neurological factors behind depression relapse, a common challenge in mental health recovery.Today in Detroit

Major depressive disorder is often a chronic condition rather than a one-time occurrence. Research indicates that many individuals who experience improvement through treatment may find their symptoms worsening again before reaching a prolonged remission, a process known as relapse. Experts share common triggers of depression relapse and strategies to proactively reduce the risk.

Why it matters

Depression is a widespread mental health issue that can significantly impact a person's quality of life. Understanding the factors that contribute to relapse and implementing preventative measures can help those struggling with depression maintain their progress and avoid the debilitating cycle of recurring episodes.

The details

According to Kimber Shelton, PhD, a licensed counseling psychologist, relapse is a common part of the recovery process. Data shows that approximately 70 percent of people who achieve partial remission of major depressive disorder will relapse, typically within the first four months. Common triggers of depression relapse include medication changes, stressful life events and trauma, new medical diagnoses, postpartum factors, seasonal changes, and significant dates that remind individuals of past trauma. Race-based trauma is also a significant factor, with a study finding that 65 percent of Black women in Detroit reported experiencing racism, and nearly 37 percent had high depressive symptoms.

  • The research noted that frequent racism experienced before age 20 was linked to an increased risk of high depressive symptoms in adulthood.

The players

Kimber Shelton

A licensed counseling psychologist who states that relapse is a common part of the recovery process for major depressive disorder.

Manish Sapra

The executive director of behavioral health services at Northwell Health, who emphasizes that while treatment reduces the probability of relapse, the condition requires active daily work.

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What they’re saying

“Relapse is a part of recovery. When you have this mindset, you're less likely to feel hopeless when you feel depressed at another point in your life”

— Kimber Shelton, PhD, licensed counseling psychologist

What’s next

Early intervention is key when symptoms begin to return. Seeking help from a mental health professional as soon as worsening symptoms appear can prevent the accumulation of shame, guilt, and hopelessness, making recovery easier.

The takeaway

While there is no guaranteed way to prevent a relapse, there are proactive steps individuals can take to lower the probability of recurrence and reduce the impact of triggers, such as identifying personal triggers, maintaining routines, building support networks, and optimizing their treatment plan.