Medusa, a 'Love Letter to Sicily,' Opens in Midtown Detroit

Chef Anthony Lombardo's newest restaurant venture pays homage to the flavors of Sicily in the heart of Detroit.

Jan. 28, 2026 at 2:31pm

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Chef Anthony Lombardo, known for the acclaimed SheWolf Pastificio & Bar, has opened a new restaurant called Medusa in Midtown Detroit. Medusa is a 'love letter to Sicily,' featuring a menu that highlights the dynamic flavors of the Mediterranean island, including handmade pastas, couscous, and seafood dishes.

Why it matters

The opening of Medusa marks Lombardo's continued investment in Detroit's dining scene, building on the success of SheWolf. The new restaurant aims to introduce Detroiters to the rich culinary heritage of Sicily, offering a unique dining experience in the city's Midtown neighborhood.

The details

Medusa is located at 644 Selden St., just steps away from Lombardo's first restaurant, SheWolf. The new space underwent a major redesign and remodel, resulting in a dining room that seats fewer than 100 guests. The menu features a variety of Sicilian-inspired dishes, including handmade busiate pasta, couscous, and seafood plates. Lombardo has invested in new equipment, including a custom pasta machine and a commercial steamer, to ensure the authenticity of the Sicilian offerings.

  • Medusa opened in January 2026.
  • The restaurant is open Thursday through Monday evenings.
  • Medusa is offering a special 5-course Valentine's Day chef's tasting menu in February 2026.

The players

Anthony Lombardo

Chef and owner of Medusa and the acclaimed SheWolf Pastificio & Bar in Midtown Detroit.

SheWolf Pastificio & Bar

Lombardo's first restaurant in Midtown Detroit, which pays homage to Roman fare.

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What they’re saying

“We'll be one of the only places in the country really making this pasta.”

— Anthony Lombardo, Chef (Detroit Free Press)

What’s next

Medusa is offering a special 5-course Valentine's Day chef's tasting menu in February 2026, with vegetarian and omnivore options.

The takeaway

The opening of Medusa in Midtown Detroit showcases Chef Anthony Lombardo's commitment to bringing the rich culinary traditions of Sicily to the city, building on the success of his first restaurant, SheWolf. The new restaurant aims to offer Detroiters a unique dining experience that celebrates the dynamic flavors of the Mediterranean island.