OS Therapies Short Interest Surges 42%

Biopharmaceutical company sees significant increase in short positions on its stock.

Published on Mar. 2, 2026

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OS Therapies Incorporated (NYSEAMERICAN:OSTX), a clinical-stage biopharmaceutical company focused on osteosarcoma and other solid tumors, saw a significant 42.2% increase in short interest on its stock in February. As of February 13th, 1,372,865 shares were sold short, representing 4.3% of the company's total shares outstanding.

Why it matters

The sharp rise in short interest on OS Therapies' stock could signal that some investors are betting against the company's future performance or are seeking to profit from a potential decline in the share price. This could put downward pressure on the stock and impact the company's ability to raise capital or make strategic moves.

The details

According to the report, the days-to-cover ratio, which measures the number of days it would take to cover all the short positions, is currently 2.1 days based on the average daily trading volume of 662,229 shares. The increase in short interest comes as OS Therapies continues to advance its pipeline of treatments for osteosarcoma and other solid tumors, including its off-the-shelf immunotherapy OST-HER2 and its antibody-drug conjugate technology OST-tADC.

  • As of February 13th, 2026, there was short interest totaling 1,372,865 shares.
  • This represents a 42.2% increase from the January 29th total of 965,726 shares.

The players

OS Therapies Incorporated

A clinical-stage biopharmaceutical company focused on developing treatments for osteosarcoma and other solid tumors.

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The takeaway

The surge in short interest on OS Therapies' stock could signal increased skepticism about the company's prospects, which could impact its ability to raise capital and execute on its strategic plans. Investors will be closely watching the company's progress in advancing its pipeline and any potential impact the short interest may have on the stock price.