Report Examines Rise in Colorectal Cancer Rates Among Young Adults

Researchers work to determine causes of increase in distal colon and rectal cancers

Mar. 2, 2026 at 9:23pm

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A new American Cancer Society report has found that colorectal cancer is now the top cancer killer for adults under 50. The report examines the rise in colorectal cancer rates in people under 65, which is largely driven by an increase in cancers in the distal colon and rectum. Researchers are working to understand the potential factors behind this trend, including the gut microbiome, diet, lifestyle, and other environmental influences.

Why it matters

The rise in colorectal cancer among younger adults is a concerning public health issue, as this type of cancer is typically more aggressive and harder to treat when detected at a later stage. Understanding the underlying causes could lead to earlier screening, prevention, and more effective interventions.

The details

The report shows the increase in colorectal cancer is driven largely by a rise in cancers in the distal colon, the last section of the colon next to the rectum, and the rectum itself. Researchers are exploring potential factors like the gut microbiome, diet, lifestyle, and environmental exposures that could be contributing to this trend. Dr. Ekta Gupta, chief of gastroenterology at the University of Maryland Medical Center-Midtown, urges anyone with even small changes in bowel habits or unexplained weight loss to contact their doctor immediately.

  • The American Cancer Society report was published on March 3, 2026.

The players

American Cancer Society

A nationwide, community-based voluntary health organization dedicated to eliminating cancer as a major health problem.

Dr. Ekta Gupta

Chief of gastroenterology at the University of Maryland Medical Center-Midtown and director of the Division of Gastroenterology and Hepatology Outpatient.

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What they’re saying

“What we have learned so far is that there could be a gut microbiome, which could be a primary driver, along with diet and lifestyle, along with processed diet. It also involves whether someone is having a more active lifestyle vs. sedentary, and whether there is alcohol or smoking involved.”

— Dr. Ekta Gupta, Chief of Gastroenterology

What’s next

Researchers will continue to investigate the potential causes behind the rise in colorectal cancer rates among younger adults, with the goal of developing more effective prevention and early detection strategies.

The takeaway

This report highlights the urgent need to better understand the factors driving the increase in colorectal cancer among younger populations, so that public health interventions can be tailored to address this growing concern and save lives.