1000-Lb. Sisters' Tammy Slaton Addresses 'Manic Depression' Struggles

The reality star reveals her mental health issues were caused by her medication dosage.

Published on Feb. 23, 2026

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Tammy Slaton, star of the reality show '1000-Lb. Sisters', has been experiencing mood swings and mental health struggles that she says were caused by the high dosage of medication she was taking before her dramatic weight loss. In an exclusive clip, Slaton shares that she has been seeing a therapist and her doctor has adjusted her prescriptions to address the 'manic depression' that was causing her to have 'mental breakdowns'.

Why it matters

Tammy Slaton's openness about her mental health struggles and the underlying medical causes highlights the importance of monitoring medication dosages, especially during significant weight changes. Her story can help raise awareness about the mental health challenges that some individuals face during their weight loss journeys.

The details

In the clip, Slaton reveals that her recent mood swings and lack of interest in family activities prompted her to seek professional help. After consulting with a therapist and her doctor, she learned that the high dosage of her previous medications was contributing to her 'manic depression' state and causing her to have 'mental breakdowns'. Her doctor has since adjusted her prescriptions to better suit her current body size and weight.

  • Tammy Slaton started seeing a therapist after her then-girlfriend Andrea Dalton threatened to end their relationship due to Tammy's outbursts and added stress.
  • Tammy Slaton went to the doctor, who did blood work and determined her medication dosage was too high for her current body size after her weight loss.

The players

Tammy Slaton

The 39-year-old star of the reality show '1000-Lb. Sisters', who has been struggling with her mental health and the side effects of her medication.

Andrea Dalton

Tammy Slaton's then-girlfriend, who threatened to end their relationship due to Tammy's mood swings and added stress.

Chris Slaton

Tammy's brother, who questioned her lack of interest in the family trip to New Orleans.

Misty Slaton

Tammy's sister, who joined Chris in questioning Tammy about her recent behavior.

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What they’re saying

“Tammy's acting like she don't want to hear nothing about the vacation. At any other time, she'd have been the first one in the car ready to go. So for her not wanting to take off and go on a trip, that right there tells you something ain't right.”

— Chris Slaton

“Since I talked to Andrea, I've had a couple appointments for therapy. Also, I went to the doctors. They did a bunch of blood work and my medication, it was such a high dose for my bigger body and now that I'm not so big, it was too high for my body size. It just kind of put me in, I guess, a manic depression state and it was making me have a mental breakdown. So they took me off five prescriptions that I didn't need anymore, and then they lowered the rest of them.”

— Tammy Slaton

What’s next

Tammy Slaton will continue to work with her therapist and doctor to monitor her mental health and medication adjustments.

The takeaway

Tammy Slaton's story highlights the importance of closely managing medication dosages, especially during significant weight changes, to avoid potential mental health issues. Her openness about seeking professional help can inspire others facing similar challenges to prioritize their overall well-being.