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Former FBI Official Weighs In on Nancy Guthrie Case
DNA evidence emerges in high-profile disappearance case
Published on Feb. 18, 2026
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In a new interview, retired FBI agent and former Chicago police superintendent Jody Weis provides insight and context on the ongoing investigation into the disappearance of Nancy Guthrie, a prominent Tucson, Arizona woman who went missing in 2025. Weis discusses the latest developments, including the emergence of new DNA evidence, and shares his expertise on how law enforcement typically handles such high-profile cases.
Why it matters
The disappearance of Nancy Guthrie has captivated national attention, with the case remaining unsolved for over a year. Weis's perspective as a former top law enforcement official could shed light on the challenges investigators face and the potential next steps in the search for answers.
The details
Weis, who previously served as the superintendent of the Chicago Police Department and as a special agent with the FBI, discusses the latest developments in the Guthrie case, including the discovery of DNA evidence that could provide crucial clues about what happened to the missing woman. He also shares his insights on how law enforcement typically approaches high-profile missing persons cases, from managing the media attention to coordinating search efforts and analyzing potential ransom demands.
- Nancy Guthrie went missing in Tucson, Arizona in January 2025.
- New DNA evidence in the case emerged in February 2026.
The players
Jody Weis
A retired FBI agent and former superintendent of the Chicago Police Department, Weis provides expert analysis on the Nancy Guthrie disappearance case.
Nancy Guthrie
A prominent Tucson, Arizona woman who went missing in 2025, sparking a high-profile investigation that has yet to yield answers.
What they’re saying
“In a case like this, law enforcement has to be very methodical and thorough in their investigation. They'll be looking at every possible lead and piece of evidence, no matter how small, to try to determine what happened.”
— Jody Weis, Retired FBI Agent and Former Chicago Police Superintendent (The National News Desk)
What’s next
Authorities in Tucson are expected to provide an update on the case and the new DNA evidence in the coming weeks.
The takeaway
The disappearance of Nancy Guthrie remains a complex and high-stakes investigation, with former law enforcement officials like Jody Weis providing valuable insight into how such cases are typically handled and the challenges investigators face in piecing together the details.
