Patrick Dempsey Reflects on His 'Grey's Anatomy' Legacy

The actor discusses his ongoing connection to the hit medical drama and his late co-star Eric Dane.

Mar. 17, 2026 at 2:55pm

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Over 10 years after Patrick Dempsey exited Grey's Anatomy when his iconic character Dr. Derek Shepherd died, he reflected on his connection to the series and where he stands with it now. Dempsey noted that the show has had a lasting impact, with many people pursuing medical careers because of it. He also discussed using his platform from the show to raise awareness for his cancer nonprofit, and the relationships he's maintained with his former co-stars, including the late Eric Dane.

Why it matters

Dempsey's comments provide insight into the enduring legacy of Grey's Anatomy and the profound impact the show has had, both on its viewers and the actors who starred in it. His reflections on his character's lasting influence and his continued involvement with the Grey's community highlight the show's cultural significance.

The details

In an interview with The Hollywood Reporter, Dempsey reflected on his time on Grey's Anatomy, saying that 'so many people have gone into the profession because of that show' and that it 'seems like it never goes away.' He also noted that he uses the platform the show has given him to spread awareness about his cancer nonprofit, The Dempsey Center. Dempsey also discussed his continued relationships with his former co-stars, including the late Eric Dane, who played Dr. Mark Sloan on the show. Dempsey called Dane 'the funniest man' and said he wants to remember him 'in that spirit.'

  • Dempsey exited Grey's Anatomy in 2014 when his character, Dr. Derek Shepherd, died.
  • Dempsey's co-star, Eric Dane, passed away last month due to his ALS battle.

The players

Patrick Dempsey

An American actor best known for his role as Dr. Derek Shepherd on the hit medical drama Grey's Anatomy.

Eric Dane

An American actor who played Dr. Mark Sloan on Grey's Anatomy for seven seasons.

Ellen Pompeo

An American actress who has played the lead role of Dr. Meredith Grey on Grey's Anatomy since the show's inception.

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What they’re saying

“So many people have gone into the profession because of that show, continually. It's an evergreen. It seems like it never goes away. I think that's a really beautiful legacy.”

— Patrick Dempsey

“He was the funniest man. He's such a joy to work with, and I want to just remember him in that spirit. Anytime he was on set, he brought so much fun to it.”

— Patrick Dempsey

The takeaway

Dempsey's reflections on his time on Grey's Anatomy and the lasting impact of the show highlight the profound cultural significance of the long-running medical drama. His continued involvement with the Grey's community and his efforts to honor his late co-star Eric Dane demonstrate the enduring bonds forged on the set of the show.