Best Medicine's Surprise Rom Com Twist Delights Abigail Spencer

The actress shares her thoughts on the sweet meet cute between Louisa and Martin.

Published on Feb. 10, 2026

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Best Medicine, the new Fox medical dramedy, has been delivering some unexpected romantic moments, including a surprise kiss between the lead characters Louisa and Martin. Actress Abigail Spencer, who plays Louisa, recently shared her thoughts on the show's meet cute between the two characters and how the kiss has shifted their dynamic going forward.

Why it matters

Best Medicine has been balancing medical drama with a budding romance, which has helped keep viewers engaged. Spencer's insights into the development of Louisa and Martin's relationship provide valuable context for fans as the show continues to explore their growing connection.

The details

In a recent interview, Spencer discussed the initial awkward meeting between Louisa and Martin in the show's first episode, noting that she loved how it unfolded without immediately explaining Louisa's frazzled state. She also talked about how the surprise kiss at the end of the latest episode, after Louisa won a blueberry pie contest, has shifted her character into being a "woman on the verge." Spencer is excited to continue exploring this new phase of Louisa's journey.

  • The meet cute between Louisa and Martin happened in the first moments of the series.
  • The surprise kiss occurred at the end of Episode 6, titled "Eyewitness Blues".
  • The next new episode of Best Medicine is scheduled to air on Tuesday, February 17, 2026.

The players

Abigail Spencer

The actress who portrays the character of Louisa on the Fox medical dramedy Best Medicine.

Louisa

The female lead character on Best Medicine, described by Spencer as a "really, really good-natured, warm-hearted school teacher that's suddenly become the town tempest."

Martin

The male lead character on Best Medicine, a doctor played by actor Josh Charles.

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What they’re saying

“What I loved is that we didn't explain everything up front. It's a meet cute between Dr. Best and Louisa, and they don't like each other. I like that she gets it wrong and he gets it wrong, and then what's next? And I really loved it. It was a great way to meet her, and the way that [showrunner] Liz [Tuccillo] described her was kind of like a really, really good-natured, warm-hearted school teacher that's suddenly become the town tempest.”

— Abigail Spencer, Actress (CinemaBlend)

“She's just ended her eight-year relationship in a small town where everybody talks. And I think being able to do a bold move like that moves her into a woman on the verge. I love playing women on the verge.”

— Abigail Spencer, Actress (CinemaBlend)

What’s next

The next new episode of Best Medicine is scheduled to air on Tuesday, February 17, 2026, where fans will see what happens next for Louisa and Martin after their surprise kiss.

The takeaway

Best Medicine's blending of medical drama and budding romance has resonated with viewers, and the show's lead actress Abigail Spencer is excited to continue exploring her character Louisa's journey, especially now that she has taken a bold step forward in her relationship with Dr. Martin Best.