JPMorgan Chase Reduces Stake in Twist Bioscience

Financial giant sells over 420,000 shares of the synthetic biology company

Mar. 3, 2026 at 1:07am

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JPMorgan Chase & Co. has reduced its holdings in Twist Bioscience Corporation (NASDAQ:TWST) by 29.2% during the third quarter, according to the company's latest 13F filing with the SEC. The firm now owns 1,018,234 shares of the company's stock, worth $28.65 million, after selling 420,892 shares.

Why it matters

Twist Bioscience is a leading player in the synthetic biology industry, known for its proprietary DNA synthesis platform. JPMorgan Chase's reduced stake could signal a shift in investor sentiment around the company, though Twist remains a top pick among many Wall Street analysts.

The details

According to the 13F filing, JPMorgan Chase sold 420,892 shares of Twist Bioscience during the third quarter, reducing its total position to 1,018,234 shares. The firm now owns 1.69% of Twist's outstanding shares, down from 2.39% previously. The sale comes as Twist Bioscience's stock has seen significant volatility in recent months, trading between $23.30 and $57.88 over the past 52 weeks.

  • JPMorgan Chase filed the 13F report disclosing the stake reduction on March 1, 2026.
  • The share sale occurred during the third quarter of 2025.

The players

JPMorgan Chase & Co.

A multinational investment bank and financial services company headquartered in New York City.

Twist Bioscience Corporation

A synthetic biology company specializing in the development and commercialization of DNA-based products and solutions, headquartered in South San Francisco, California.

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What they’re saying

“We must not let individuals continue to damage private property in San Francisco.”

— Robert Jenkins, San Francisco resident

The takeaway

JPMorgan Chase's reduced stake in Twist Bioscience reflects the volatility in the synthetic biology sector, though the company remains a leader in its field and a top pick among many analysts. The move highlights the importance of diversification and ongoing monitoring of investment portfolios in a rapidly evolving industry.