DJ Khaled Touts Wegovy Pill in Star-Studded Super Bowl LX Ad

The 'We The Best' rapper joins Kenan Thompson, John C. Reilly and Ana Gasteyer in promoting the new weight loss medication

Feb. 6, 2026 at 8:55am

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DJ Khaled is one of several stars who will appear in a 90-second Super Bowl LX commercial on Sunday (Feb. 8) during the big game touting the benefits of the new Wegovy pill, a GLP-1 weight loss medication. The spot features Khaled alongside SNL's Kenan Thompson, actor John C. Reilly, and former SNL cast member Ana Gasteyer humorously describing other useful pills they'd take.

Why it matters

The ad is the first-ever one featuring Novo Nordisk's new once-daily Wegovy 25mg tablets, introducing the anticipated pill while addressing public perceptions that taking weight loss medications is 'the easy way out.' Instead, it stresses that adults with obesity can lose weight using the Wegovy pill, along with diet and exercise.

The details

In the spot, Kenan Thompson stands atop a water tower to announce that 'Wegovy now comes in a pill,' as the excitable Khaled shouts up to him from the ground. The ad, set to Skee-Lo's 1995 hit 'I Wish,' features the stars describing other useful pills they'd take, including Reilly wishing for one to help him parallel park and Gasteyer dreaming of a pill to make people 'less judgy about how to lose weight.'

  • The Super Bowl LX commercial will air on Sunday, February 8, 2026.

The players

DJ Khaled

A rapper, record producer, and media personality known for his hit songs and energetic personality.

Kenan Thompson

A longtime cast member of Saturday Night Live, known for his comedic acting skills.

John C. Reilly

An acclaimed actor known for his roles in films like Step Brothers and Guardians of the Galaxy.

Ana Gasteyer

A former cast member of Saturday Night Live, known for her comedic talents and versatility.

Novo Nordisk

A global healthcare company that develops and markets pharmaceutical products, including the Wegovy weight loss medication.

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What they’re saying

“Wegovy now comes in a pill, so adults with obesity can lose weight and keep it off along with diet and exercise!”

— Kenan Thompson

“I knew I wanted to work with Novo Nordisk because I'm a father, I'm a husband, and I want to be the best for my family. When you're trying to reach your goals and you're looking for something more, having an option like Wegovy® pill – that's powerful.”

— DJ Khaled

What’s next

The Super Bowl LX commercial featuring DJ Khaled and other stars promoting the Wegovy pill will air during the big game on Sunday, February 8, 2026.

The takeaway

This star-studded ad campaign aims to destigmatize the use of weight loss medications like Wegovy, positioning them as a tool that can help adults with obesity achieve their health goals when combined with diet and exercise, rather than as an 'easy way out.'