6 Hospitalized After Crash in San Francisco's Mission District

Two pedestrians suffered life-threatening injuries in the collision.

Mar. 14, 2026 at 1:08am by Ben Kaplan

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A car struck two pedestrians and another vehicle on 22nd Street at the intersection of South Van Ness in San Francisco's Mission District on Friday afternoon, leaving six people hospitalized, including two pedestrians with life-threatening injuries.

Why it matters

Pedestrian safety is an ongoing concern in San Francisco, especially in high-traffic areas like the Mission District. This incident highlights the need for improved traffic safety measures and driver awareness to protect vulnerable road users.

The details

According to police and fire officials, the car struck two pedestrians and another oncoming vehicle. The two pedestrians were rushed to San Francisco General Hospital with life-threatening injuries, while four others from the vehicles sustained minor injuries. When authorities arrived, the scene was chaotic, with shoes, clothes, and a slipper strewn across the street.

  • The incident occurred on Friday afternoon.

The players

Bill Storti

Fire Department Assistant Chief who confirmed the details of the incident.

Amerie Wheeler

A local resident who heard the crash and went outside to see the aftermath.

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What they’re saying

“I was in my home when I heard the sound of brakes screeching followed by a 'big crash' and someone screaming something like 'Help,' 'Call 911,' and 'Oh my god,'”

— Amerie Wheeler, Local resident (missionlocal.org)

“I was under the impression that both pedestrians would survive the incident.”

— Bill Storti, Fire Department Assistant Chief (missionlocal.org)

What’s next

Authorities are investigating the cause of the crash and will likely release more details in the coming days.

The takeaway

This incident underscores the ongoing need for improved pedestrian safety measures in San Francisco's busy neighborhoods, as well as the importance of driver awareness and responsibility to prevent such tragic collisions.