Eric Dane, 'Grey's Anatomy' Star, Dies at 53

The actor's cause of death was respiratory failure due to amyotrophic lateral sclerosis (ALS).

Published on Mar. 2, 2026

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Eric Dane, the actor known for his role as Dr. Mark Sloan on the medical drama "Grey's Anatomy," has died at the age of 53. According to a death certificate from the Los Angeles County Department of Public Health, Dane's cause of death was respiratory failure, with amyotrophic lateral sclerosis (ALS) listed as an underlying cause.

Why it matters

Dane's death shines a light on the devastating impact of ALS, a rare and incurable neurodegenerative disease. His passing will be felt deeply by his many fans and the "Grey's Anatomy" community, as he was a beloved and iconic character on the long-running show.

The details

Dane revealed in April 2025 that he had been battling ALS for a year and a half prior to that point. In a statement, his family said he spent his final days surrounded by close friends, his wife actress Rebecca Gayheart, and their two daughters, Billie and Georgia, who were the center of his world.

  • Eric Dane died on February 19, 2026.
  • Dane revealed his ALS diagnosis in April 2025.

The players

Eric Dane

An American actor best known for his role as Dr. Mark Sloan on the medical drama "Grey's Anatomy".

Rebecca Gayheart

An American actress who was Dane's wife.

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What they’re saying

“He spent his final days surrounded by dear friends, his devoted wife [actress Rebecca Gayheart] and his two beautiful daughters, Billie and Georgia, who were the center of his world.”

— Dane's family (People Magazine)

The takeaway

Dane's passing is a tragic loss for the entertainment industry and a reminder of the devastating impact of ALS. His family's statement highlights the importance of cherishing loved ones in one's final days, and his openness about his diagnosis may help raise awareness and understanding of this rare disease.