Granahan Investment Management Boosts Stake in Soleno Therapeutics

Institutional investor increases ownership in biotech company developing treatment for rare genetic disorder

Mar. 16, 2026 at 10:39am

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Granahan Investment Management LLC grew its stake in Soleno Therapeutics, Inc. (NASDAQ:SLNO) by 82.2% in the third quarter, according to the company's recent 13F filing with the Securities and Exchange Commission. The investment firm now owns 109,253 shares of the company's stock, valued at $7.39 million.

Why it matters

Soleno Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapies for rare and orphan diseases, with its lead candidate DCCR being investigated for the treatment of Prader-Willi syndrome. The increase in Granahan Investment Management's stake suggests institutional confidence in the company's pipeline and future prospects.

The details

According to the 13F filing, Granahan Investment Management acquired an additional 49,276 shares of Soleno Therapeutics during the third quarter, bringing its total ownership to 109,253 shares. This represents a 0.20% stake in the company. The investment firm cited the potential of Soleno's DCCR therapy for Prader-Willi syndrome as a key factor in its decision to increase its position.

  • Granahan Investment Management increased its stake in Soleno Therapeutics during the third quarter of 2025.

The players

Granahan Investment Management LLC

An institutional investment management firm that focuses on small-cap and mid-cap equities.

Soleno Therapeutics, Inc.

A clinical-stage biopharmaceutical company developing therapies for rare and orphan diseases, including Prader-Willi syndrome.

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The takeaway

The increased investment by Granahan Investment Management in Soleno Therapeutics suggests that the institutional investor sees significant potential in the company's pipeline, particularly its lead candidate DCCR for the treatment of Prader-Willi syndrome, a rare and complex genetic disorder.