Christina Applegate Hospitalized Amid Ongoing MS Battle, Friends Fear the Worst

The 'Married... With Children' star's recent health setbacks have her loved ones deeply concerned.

Apr. 18, 2026 at 5:49pm

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An extreme close-up of a shattered, glittering disco ball reflecting a warm, faint light, conceptually representing the fragility and resilience of a celebrity's health journey.The glittering, fractured surface of a disco ball symbolizes the ups and downs of Christina Applegate's ongoing battle with multiple sclerosis.Los Angeles Today

Christina Applegate, who revealed her multiple sclerosis (MS) diagnosis in 2021, has reportedly been hospitalized again in Los Angeles, with friends and loved ones fearing the worst as they describe her ongoing battle with the autoimmune disease as 'hellish' and 'treacherous.' The 54-year-old actress has been open about her health struggles, including being confined to her bed due to pain, and her most recent hospitalization in late March has further worried those close to her.

Why it matters

Applegate's high-profile battle with MS has shed light on the challenges faced by those living with the chronic, often debilitating condition. Her openness about her journey has resonated with many fans and inspired discussions around invisible disabilities and the importance of support systems for those dealing with serious health issues.

The details

According to a report, Applegate was recently hospitalized in Los Angeles, though it remains unclear if the reason was directly related to her MS diagnosis. The actress has previously shared that she experiences both good and bad days, and has been confined to her bed due to ongoing pain. In a recent interview, Applegate said she still tries to take her daughter to school in the mornings, her 'favorite thing to do,' before returning home to rest.

  • Applegate revealed her MS diagnosis in August 2021.
  • She was hospitalized in late March 2026 for an unknown reason.
  • In August 2025, Applegate was hospitalized for a kidney infection that had spread to both kidneys.

The players

Christina Applegate

A 54-year-old actress best known for her role on the sitcom 'Married... With Children,' who revealed her multiple sclerosis diagnosis in 2021 and has been open about her ongoing health struggles.

Martyn LeNoble

Applegate's husband, with whom she shares a daughter named Sadie.

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What they’re saying

“With every setback, if we are being realistic, everyone has it in the back of their minds that they might not have a tomorrow with her.”

— Source

“But when she does look at things positively it makes her feel better in the moment because she has so many friends that are there for her, even to listen to her, cry with her and anything in between.”

— Source

What’s next

Applegate's representatives have not provided any updates on her current condition or the reason for her recent hospitalization. Her fans and loved ones remain deeply concerned for her health and well-being as she continues to navigate her battle with multiple sclerosis.

The takeaway

Christina Applegate's openness about her MS diagnosis and ongoing health struggles has resonated with many, shining a light on the challenges faced by those living with invisible disabilities. Her story underscores the importance of strong support systems and the need for continued awareness and understanding around chronic, debilitating conditions.