Christina Applegate Hospitalized Amid Ongoing MS Battle

The actress' representative addresses reports of her recent hospitalization in Los Angeles.

Apr. 17, 2026 at 4:51am

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An extreme macro photograph of Christina Applegate's hand, the skin textured and delicate, capturing the physical toll of her multiple sclerosis diagnosis in a conceptual, high-contrast studio portrait.A close-up portrait of the physical effects of multiple sclerosis on actress Christina Applegate's hands, a poignant symbol of her ongoing health struggles.Los Angeles Today

Christina Applegate's representative has confirmed that the 54-year-old actress has been hospitalized in Los Angeles since late March, amid her ongoing battle with multiple sclerosis (MS), an autoimmune disease she was diagnosed with in 2021. Applegate's rep stated that she has a 'long history of complicated medical conditions' that she has been open about, including frequent hospitalizations for issues like severe pain, vomiting, and diarrhea.

Why it matters

Applegate's openness about her health struggles with MS has helped raise awareness and understanding of the debilitating effects of the disease. Her recent hospitalization underscores the challenges she continues to face and the importance of providing support and resources for those living with chronic, autoimmune conditions.

The details

According to reports, Applegate has been receiving medical treatment in Los Angeles since late March. Her representative declined to provide specifics on her current condition or treatment, stating that Applegate has a 'long history of complicated medical conditions' that she has been transparent about in the past. This includes being hospitalized 'upwards of 30 times' since her 2021 diagnosis due to issues like severe pain, vomiting, and diarrhea. Applegate has also previously shared that she struggles with tasks like holding a phone or remote control due to the effects of MS on her body.

  • Applegate was diagnosed with multiple sclerosis in 2021.
  • She has been hospitalized in Los Angeles since late March 2026.
  • In November 2024, Applegate discussed her ongoing battle with MS symptoms on her podcast 'MeSsy'.
  • In March 2026, Applegate revealed she had purchased her own burial plot, citing concerns about the impact her death would have on her 15-year-old daughter.

The players

Christina Applegate

A 54-year-old actress who was diagnosed with multiple sclerosis in 2021 and has been open about her ongoing health struggles with the autoimmune disease.

Applegate's representative

The spokesperson who addressed reports of Applegate's recent hospitalization in Los Angeles.

Jamie-Lynn Sigler

An actress who co-hosts the 'MeSsy' podcast with Applegate, where they have discussed their experiences living with multiple sclerosis.

Martyn LeNoble

Applegate's husband and the father of her 15-year-old daughter, Sadie.

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What they’re saying

“'She's had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast.'”

— Applegate's representative

“'Jamie and I have different — everybody has different ways of it showing up. I lay in bed screaming. Like, the sharp pains, the ache, that squeezing.'”

— Christina Applegate

“'I can't even pick up my phone sometimes, because now it's traveled into my hands. So I'll try to go get my phone, or get my remote to turn on the TV [and] sometimes, I can't even hold them. I can't open bottles now.'”

— Christina Applegate

“'I'm very not comfortable because I'm going to hurt my kid. I think it's — now I'm, like, really afraid of it because of her. I can't — I don't know. I can't even talk about, like, I don't know what her life's going to be like, and you don't know when it's going to be — could be, like, anytime.'”

— Christina Applegate

What’s next

Applegate's representative stated they have no further comment on her current medical status or treatment plan. Fans and the public will likely continue to follow updates on her health and advocacy efforts related to multiple sclerosis.

The takeaway

Christina Applegate's ongoing battle with multiple sclerosis serves as a poignant reminder of the immense physical and emotional challenges faced by those living with chronic, debilitating autoimmune diseases. Her openness about her struggles has helped raise awareness and understanding, while also highlighting the need for continued research, resources, and support for MS patients and their families.