Remembering Eric Dane

Actor known for 'Grey's Anatomy' dies at 54 after battle with ALS

Feb. 28, 2026 at 8:15pm

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Eric Dane, the actor best known for his role as Dr. Mark Sloan on the hit medical drama series 'Grey's Anatomy', has passed away at the age of 54 after a battle with amyotrophic lateral sclerosis (ALS). Dane was a beloved figure in Hollywood, earning critical acclaim for his portrayal of the charming and skilled plastic surgeon on the long-running show.

Why it matters

Dane's death is a major loss for the entertainment industry, as he was considered one of the most talented and charismatic actors of his generation. His role on 'Grey's Anatomy' made him a household name and he had a successful career in both television and film. Dane's openness about his ALS diagnosis also helped raise awareness about the debilitating disease.

The details

Dane was first diagnosed with ALS, also known as Lou Gehrig's disease, in 2023. The progressive neurodegenerative disorder ultimately claimed his life on February 19, 2026. Despite his declining health, Dane continued to act when possible, making his final on-screen appearance in a 2025 episode of 'Grey's Anatomy' that served as a tribute to his character.

  • Eric Dane was first diagnosed with ALS in 2023.
  • Dane passed away on February 19, 2026 at the age of 54.

The players

Eric Dane

An American actor best known for his role as Dr. Mark Sloan on the medical drama series 'Grey's Anatomy'.

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What they’re saying

“Eric was a beloved member of the 'Grey's Anatomy' family and his passing is a tremendous loss. He brought so much joy and humanity to his character and will be deeply missed.”

— Shonda Rhimes, Creator of 'Grey's Anatomy'

The takeaway

Dane's death is a somber reminder of the devastating impact of ALS, a disease that robs individuals of their physical abilities over time. His legacy, however, will live on through his iconic performances and the indelible mark he left on the entertainment industry and his legions of fans.