Doctors Reveal Top Sign of Lung Cancer to Watch For

Plus, what to know before making an appointment.

Mar. 31, 2026 at 5:31pm

A ghostly, translucent X-ray photograph revealing the internal structures of human lungs, conceptually representing the early detection of lung cancer.An X-ray view of the lungs can help detect early signs of cancer, allowing for prompt treatment.Long Beach Today

Lung cancer is one of the deadliest forms of cancer in the U.S., but doctors say there is one common symptom to watch out for - a persistent cough that doesn't go away with typical treatment. While lung cancer often doesn't cause symptoms until it's advanced, experts recommend seeing a doctor if a cough lasts more than 2-3 weeks, especially for those with a history of smoking.

Why it matters

Lung cancer is the leading cause of cancer deaths in the U.S., surpassing even prostate, breast, and colon cancers combined. While smoking is the biggest risk factor, exposure to radon gas is also a top cause. Knowing the early warning signs can help with earlier detection and treatment.

The details

According to the experts, a persistent cough that doesn't improve with supportive care or antibiotics is one of the most common signs of lung cancer. Other potential symptoms include coughing up blood, unexplained weight loss, chest pain, and shortness of breath. However, these symptoms can also be caused by other conditions, so doctors recommend getting evaluated if any persist for more than a couple weeks, especially for those with a history of smoking.

  • Lung cancer is most commonly diagnosed in people over age 65, per the American Cancer Society.

The players

David Yashar, M.D.

A hematologist-medical oncologist at MemorialCare Cancer Institute at Long Beach Medical Center in Long Beach, CA.

Jimmy Johannes, M.D.

A pulmonologist and critical care medicine specialist at MemorialCare Medical Group in Long Beach, CA.

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What they’re saying

“One common sign is a persistent cough that does not get better despite supportive care or antibiotics. If the cough is persistent for more than 2-3 weeks, I would call a doctor for further evaluation.”

— David Yashar, M.D., Hematologist-Medical Oncologist

“Often, lung cancer doesn't cause any symptoms until it is advanced. The signs and symptoms that can suggest lung cancer are often explained by other conditions or factors, and lung cancer may be a less likely reason for the symptoms.”

— Jimmy Johannes, M.D., Pulmonologist and Critical Care Medicine Specialist

What’s next

If the suspicion of lung cancer is high enough based on symptoms, doctors may order a chest X-ray and CT scan to look for any lung nodules or masses. Depending on the findings, further testing and treatment can be determined.

The takeaway

Lung cancer is a serious disease, but knowing the early warning signs like a persistent cough can help with earlier detection and treatment. Those with a history of smoking or other risk factors should not hesitate to see a doctor if they experience any concerning symptoms.