Epione Institute Unveils Regenerative Facial Protocol with Clinical Evidence

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Epione Beverly Hills has introduced a novel regenerative facial protocol designed to support biological skin rejuvenation rather than traditional lifting or filling techniques. Developed by Dr. Simon Ourian, the method combines Neustem™ and Coolaser® technologies to encourage tissue regeneration at the cellular level. Multi-year clinical data indicate measurable improvements in skin quality, elasticity, firmness, and structural integrity.

Why it matters

This regenerative approach focuses on restoring the skin's natural function rather than mechanically altering its appearance, offering a long-term biological complement to traditional cosmetic procedures. The protocol has been successfully applied to patients with and without prior surgical facelifts, defining a new category within aesthetic medicine that emphasizes gradual, natural improvement over immediate cosmetic change.

The details

In independent evaluations involving 85 patients, regenerative biomarkers increased between 70% and over 200% compared to legacy non-surgical treatments. A five-year retrospective analysis of 520 patients further confirmed the protocol's effectiveness and durability, with dermal thickness and density increasing by 18–22%, firmness and tissue recoil improving by 15–20%, and structural stability enhancements observed in approximately 80% of cases.

• The protocol has been applied successfully to patients over the past five years.
• A five-year retrospective analysis of 520 patients was conducted.

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