Skin Reactions to COVID Vaccines Underrated, Warns Medical Journal

The Journal of American Physicians and Surgeons says skin issues from mRNA vaccines have been dismissed as 'irrelevant'.

Published on Mar. 10, 2026

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According to an article in the Journal of American Physicians and Surgeons, the skin-related adverse effects of COVID vaccines have been overlooked and dismissed as unimportant by experts and the public, despite the skin's crucial role in the body's immune, neurological, and endocrine functions. The article argues that the potential interference of mRNA vaccines with the skin's vital functions could have serious systemic consequences for patients' health.

Why it matters

The skin is a complex 'super-organ' that coordinates many essential bodily functions, so disruptions to the skin from vaccines could have wide-ranging impacts on health that have been underappreciated. This raises concerns about the risk-benefit profile of the new mRNA vaccine technology, which introduces novel mechanisms like lipid nanoparticles that may trigger harmful skin reactions.

The details

The article, written by Jane M. Orient, M.D., states that while the lay public may not recognize the significance of skin pathologies, their neglect by regulators is unexpected since they know the dangers exceed mere cosmetic issues. The skin is part of the recently discovered cutaneous-immuno-neuro-endocrine (CINE) system, coordinating immune responses, thermoregulation, and chemical homeostasis, as well as producing neuropeptides, neurotransmitters, and hormones. The potential interference of mRNA vaccines with these crucial skin functions 'may have very serious systemic consequences' for patient health.

  • The article was published in the spring 2026 issue of the Journal of American Physicians and Surgeons.

The players

Jane M. Orient, M.D.

The author of the article published in the Journal of American Physicians and Surgeons, who argues that the skin-related adverse effects of COVID vaccines have been dismissed as 'irrelevant' by experts.

Journal of American Physicians and Surgeons

A medical journal published by the Association of American Physicians and Surgeons, a national organization representing physicians in all specialties since 1943.

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What they’re saying

“The potential interference of mRNA vaccine with those crucial functions of the skin may have very serious systemic consequences with grave implication for patients' general health status.”

— Jane M. Orient, M.D., Author (Journal of American Physicians and Surgeons)

“The fact that the mRNA platform was implemented despite warning signs of cutaneous and other serious risks 'defies rational explanation.' Future research of risk/benefits profiles of vaccines should be driven by objectivity, not by the biased desire to 'decrease vaccine hesitancy.' Any vaccines with proven unfavorable risk/benefit ratio should be removed from the market.”

— Jane M. Orient, M.D., Author (Journal of American Physicians and Surgeons)

What’s next

The article calls for physicians to exercise 'diagnostic due diligence' when encountering cutaneous signs in vaccinated patients, suggesting further research and monitoring of the skin-related risks of mRNA vaccines is needed.

The takeaway

This case highlights growing concerns about the potential underestimation of skin-related side effects from the new mRNA COVID vaccine technology, which could have wide-ranging impacts on patient health that have been overlooked. It raises questions about the objectivity of vaccine risk-benefit assessments and the need for more rigorous safety monitoring.