DNA Evidence Yields No Matches in Nancy Guthrie Disappearance

Pima County Sheriff says DNA found near missing woman's home did not match any records in FBI database.

Feb. 19, 2026 at 1:39pm

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DNA evidence collected from a glove found near Nancy Guthrie's home in Tucson, Arizona, as well as from inside her residence, did not produce any matches in the FBI's Combined DNA Index System (CODIS) database, according to Pima County Sheriff Chris Nanos. Guthrie was forcibly taken from her home in the early morning hours of February 1, and authorities are continuing to search for her.

Why it matters

The lack of DNA matches in the FBI database is a significant development in the case, as investigators had hoped the evidence could provide crucial leads. With no matches, the search for Guthrie becomes more challenging, raising concerns about the perpetrator's identity and whereabouts.

The details

Sheriff Nanos revealed that the DNA found on the glove near Guthrie's home was different from the DNA found inside her residence. While the DNA evidence is still being analyzed, the lack of matches in the FBI's CODIS database means investigators will likely turn to investigative genetic genealogy, a technique that combines DNA analysis with searching public genealogy databases.

  • On February 1, 2026, Nancy Guthrie was forcibly taken from her Tucson, Arizona home in the early morning hours.
  • On February 17, 2026, Pima County Sheriff Chris Nanos announced that DNA evidence collected from a glove near Guthrie's home and from inside her residence did not produce any matches in the FBI's CODIS database.

The players

Chris Nanos

The Pima County Sheriff who revealed the details about the DNA evidence in the Nancy Guthrie disappearance case.

Nancy Guthrie

The woman who was forcibly taken from her Tucson, Arizona home on February 1, 2026.

Jason Pack

A retired FBI special agent who told Fox News Digital that investigators will likely turn to "Investigative genetic genealogy" since there wasn't a match for the DNA in the FBI's CODIS database.

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What they’re saying

“We're hopeful that we're always getting closer, but the news now, I think, is we had heard this morning that, of course, the DNA on the glove that was found two miles away was submitted for CODIS. And I just heard that CODIS had no hits.”

— Chris Nanos, Pima County Sheriff (Fox News)

“[Investigators] go here: Investigative genetic genealogy, or IGG, is a technique the FBI uses that combines DNA analysis from crime scenes with searching publicly available commercial genealogy databases and old-fashioned genealogy research.”

— Jason Pack, Retired FBI special agent (Fox News)

“It is never too late to do the right thing.”

— Savannah Guthrie (NBC Today)

What’s next

The Pima County Sheriff's Office said the DNA found at Nancy Guthrie's property is still being analyzed, and further testing needs to be done as part of the investigation. Investigators will likely turn to investigative genetic genealogy since there was no match in the FBI's CODIS database.

The takeaway

The lack of DNA matches in the FBI database is a significant setback in the search for Nancy Guthrie, raising concerns about the perpetrator's identity and whereabouts. Investigators will need to explore alternative forensic techniques, such as investigative genetic genealogy, to try to uncover new leads in this ongoing missing persons case.